News / Health

Gut Bacteria Increase Pre-Diabetes Risk

Jessica Berman
Certain bacteria in the human gut seem to be associated with pre-diabetes, a condition marked by a constellation of risk factors that often precedes the on-set of full-blown type 2 diabetes in humans. The finding is part of an effort to discover the role of trillions of bacteria or microbiota that live in our bodies.

According to Brandi Cantarel, the number of bacteria living happily inside us outnumbers human cells by an astounding 10-1.  Cantarel is a researcher at the Institute for Genome Science at the University of Maryland School of Medicine in Baltimore.

“With all that extra stuff, let’s say genetic material in our bodies that doesn’t come from us, it comes from other sources, we think it has to be doing something," said Cantarel. "Right?”
 
According to Cantarel, scientists believe there are over 7,000 strains of more than 1,000 different species of bacteria that live in the digestive tract, most of them in the gut or small intestine, which play a role in human health.  Many of the trillions of microbes are helpful; without them, for example, we couldn’t digest food properly.

But experts say bacteria that are out of balance could be harmful.  Researchers have identified 26 microbes that researchers say may be negatively associated with pre-diabetes or metabolic syndrome.  

Investigators studied the gut microbiota of 310 members of the Old Order Amish, a closed-knit sect of Caucasian individuals living in rural Pennsylvania that emigrated from central Europe in the 1700’s in search of religious freedom. Experts say the Amish community has less genetic variation and a similar diet, making it easier to single out risk factors that might contribute to disease.  They also take fewer medications.

Richard Horenstein, an endocrinologist at the University of Maryland, says stool samples were analyzed to identify gut microbiota in the Amish volunteers, all of whom were either overweight or obese with a range of metabolic syndrome indicators.

The samples, according to Horenstein, contained bacteria researchers were able to link to elevated blood pressure and total cholesterol levels, obesity and higher than normal levels of C-reactive protein, a marker for inflammation found to play a role in heart disease, cancer and other chronic diseases.

Horenstein says the participants fell into one of three distinct groups of gut microbiota.  The greatest number of Amish had gut bacteria often seen in farm animals.

“And may even suggest the transmission of gut microbes across species, so from man to the animals or from the animals.  And this is highly speculative," said Horenstein.

In the future, Horenstein says researchers might investigate a possible connection between human and animal microbiota. Another area of investigation, according to researchers, is to study the gut bacteria people in the general population who are of Central European descent for any similarities to the Amish population and to see whether gut microbes change over time, since most people tend to gain weight and develop chronic diseases as they age.
   
At this point, researchers say they cannot draw a direct connection between gut microbiota and pre-diabetes, so their findings cannot be used to help determine who is at risk for pre-diabetes.

An article on gut bacteria and metabolic syndrome is published in the journal PLoS One.  

You May Like

Photogallery Pistorius Sentenced, Taken to Prison

Pistorius, convicted of culpable homicide in shooting death of girlfriend Reeva Steenkamp, will likely serve about 10 months of five-year sentence, before completing it under house arrest More

UN to Aid Central Africa in Polio Vaccinations

Synchronized vaccinations will be conducted after Cameroon reports a fifth case of the wild polio virus in its territory More

WHO: Ebola Vaccine May Be in Use by Jan.

WHO assistant director Dr. Marie Paule Kieny says clinical trials of Ebola vaccines are underway or planned in Europe, US and Africa More

Featured Videos

Your JavaScript is turned off or you have an old version of Adobe's Flash Player. Get the latest Flash player.
After Decades of Pressure, Luxembourg Drops Bank Secrecy Rulesi
X
October 21, 2014 12:20 AM
European Union finance ministers have reached a breakthrough agreement that will make it more difficult for tax cheats to hide their money. The new legislation, which had been blocked for years by countries with a reputation as tax havens, was approved last week after Luxembourg and Austria agreed to lift their vetoes. But as Mil Arcega reports, it doesn’t mean tax cheats have run out of places to keep their money hidden.
Video

Video After Decades of Pressure, Luxembourg Drops Bank Secrecy Rules

European Union finance ministers have reached a breakthrough agreement that will make it more difficult for tax cheats to hide their money. The new legislation, which had been blocked for years by countries with a reputation as tax havens, was approved last week after Luxembourg and Austria agreed to lift their vetoes. But as Mil Arcega reports, it doesn’t mean tax cheats have run out of places to keep their money hidden.
Video

Video Kobani Refugees Welcome, Turkey Criticizes, US Airdrop

Residents of Kobani in northern Syria have welcomed the airdrop of weapons, ammunition and medicine to Kurdish militia who are resisting the seizure of their city by Islamic State militants. The Turkish government, however, has criticized the operation. VOA’s Scott Bobb reports from southeastern Turkey, across the border from Kobani.
Video

Video China Political Meeting Seeks to Improve Rule of Law

China’s communist leaders will host a top level political meeting this week, called the Fourth Plenum, and for the first time in the party’s history, rule of law will be a key item on the agenda. Analysts and Chinese media reports say the meetings could see the approval of long-awaited measures aimed at giving courts more independence and include steps to enhance an already aggressive and high-reaching anti-corruption drive. VOA’s Bill Ide has more from Beijing.
Video

Video US ‘Death Cafes’ Put Focus on the Finale

In contemporary America, death usually is a topic to be avoided. But the growing “death café” movement encourages people to discuss their fears and desires about their final moments. VOA’s Jerome Socolovsky reports.
Video

Video Ebola Orphanage Opens in Sierra Leone

Sierra Leone's first Ebola orphanage has opened in the Kailahun district. Hundreds of children orphaned since the beginning of the Ebola outbreak face stigma and rejection with nobody to care for them. Adam Bailes reports for VOA about a new interim care center that's aimed at helping the growing number of children affected by Ebola.
Video

Video Young Nairobi Tech Innovator on 'Track' in Security Business

A 24-year-old technology innovator in Nairobi has invented a tracking device that monitors and secures cars. He has also come up with what he claims is the most robust audio-visual surveillance system yet. As Lenny Ruvaga reports from the Kenyan capital, his innovations are offering alternative security solutions.
Video

Video Latinas Converting to Islam for Identity, Structure

Latinos are one of the fastest growing groups in the Muslim religion. According to the Pew Research Center, about 6 percent of American Muslims are Latino. And a little more than half of new converts are female. VOA’s Carolyn Presutti travelled to Miami, Florida -- where two out of every three residents is Hispanic -- to learn more.
Video

Video Exclusive: American Joins Kurds' Anti-IS Fight

The United States and other Western nations have expressed alarm about their citizens joining Islamic State forces in Syria and Iraq. In a rare counterpoint to the phenomenon, an American has taken up arms with the militants' Syrian Kurdish opponents. Elizabeth Arrott has more in this exclusive profile by VOA Kurdish reporter Zana Omer in Ras al Ayn, Syria.
Video

Video South Korea Confronts Violence Within Military Ranks

Every able-bodied South Korean male between 18 and 35 must serve for 21 to 36 months in the country’s armed forces, depending upon the specific branch. For many, service is a rite of passage to manhood. But there are growing concerns that bullying and violence come along with the tradition. Reporter Jason Strother has more from Seoul.
Video

Video North Carolina Emerges as Key Election Battleground

U.S. congressional midterm elections will be held on November 4th and most political analysts give Republicans an excellent chance to win a majority in the U.S. Senate, which Democrats now control. So what are the issues driving voters in this congressional election year? VOA National Correspondent Jim Malone traveled to North Carolina, one of the most politically competitive states in the country, to find out.
Video

Video Comanche People Maintain Pride in Their Heritage

The Comanche (Indian nation) once were called the “Lords of the Plains,” with an empire that included half the land area of current day Texas, large parts of Oklahoma, New Mexico, Kansas and Colorado.The fierceness and battle prowess of these warriors on horseback delayed the settlement of most of West Texas for four decades. VOA’s Greg Flakus reports from Lawton, Oklahoma, that while their warrior days are over, the 15,000 members of the Comanche Nation remain a proud people.
Video

Video Turkey Campus Attacks Raise Islamic Radicalization Fears

Concerns are growing in Turkey of Islamic radicalization at some universities, after clashes between supporters of the jihadist group Islamic State (IS) or ISIS, and those opposed to the extremists. Pro-jihadist literature is on sale openly on the streets of Istanbul. Critics accuse the government of turning a blind eye to radicalism at home, while Kurds accuse the president of supporting IS - a charge strongly denied. Henry Ridgwell reports from London.

All About America

AppleAndroid